Lithium shifts circadian rhythms early in bipolar disorder and may offer clues to treatment response

Lithium shifts circadian rhythms early in bipolar disorder and may offer clues to treatment response

Source: News-Medical

A randomized controlled trial shows that lithium treatment in bipolar disorder patients reduces daytime activity, advances its onset time, and increases volatility in circadian rest-activity patterns. These changes appear early and independently of mood, offering promise as early biomarkers of treatment response.

Can lithium’s effect on daily activity patterns reveal who will benefit from treatment? A six-week trial finds circadian shifts emerge early, before mood improves, hinting at a biological clue to lithium response in bipolar disorder.
Study: Effect of… [6908 chars]

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