Stalled protein processing may underlie Alzheimer’s disease

Stalled protein processing may underlie Alzheimer's disease

Source: PsyPost

Mutations in the presenilin-1 gene cause gamma-secretase to stall during protein processing, leading to stable enzyme-substrate complexes. This disruption, rather than amyloid beta buildup, may drive neurodegeneration in Alzheimer’s disease.

A recent study published in eLife offers a new perspective on the development of Alzheimer’s disease, suggesting that the condition may be triggered by disruptions in how the brain processes proteins. Researchers found that mutations in a specific ge… [8250 chars]

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